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Postdoctoral Associate - m6A RNA Biology (7224)

The Jackson Laboratory is a world leader in mammalian genetics. JAX is passionate about its mission of discovering precise genomic solutions for disease and empowering the global biomedical community in the shared quest to improve human health.
The Ke Lab is seeking a postdoctoral associate at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanism of RNA, the Ke lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative bio-technologies, genetics and molecular biology. We are especially interested in m6A RNA biology: 1) the fundamental mechanism of m6A RNA biology, and 2) the biological effects of m6A regulation in nerve system, using mouse and human iPS models. (References: 1 Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2 Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation, Genes & Development 2015, 29:2037-53.)
The successful candidate will be encouraged to develop an independent research program using a broad array of resources and expertise available to the lab (https://www.jax.org/research-and-faculty/tools/scientific-research-services). Exceptional postdoctoral candidates will have the opportunity to apply for the title of JAX Postdoctoral Scholar, an internal award addressing the national need for research scientists who are accomplished in the broadly defined fields of genetics and genomics. The award includes an independent research budget, travel funds, and a salary above standard postdoctoral scale.
The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA, is recognized internationally for its excellence in research, unparalleled mouse resources, outstanding training environment characterized by scientific collaboration, and exceptional core services - all within a spectacular setting adjacent to Acadia National Park. Translational research collaborations in genomics-based, personalized medicine are fostered through our JAX Genomic Medicine campus in Farmington, CT. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.
Required Skills
Qualified candidates will be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions, and have a Ph.D. or MD. degree with background in one of the following areas, including computational biology, biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, or cancer biology. Skills in quantitative programming or biochemistry are preferred but not required.
To apply, please submit (1) a cover letter describing past research accomplishments, research interests, and career goals, (2) a current CV, and (3) the contact information of three references.
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.



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