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Biostatistician II

Summary
Biostatistician II
The Center for Biometric Analysis (CBA) is a critical component of future JAX disease modeling and discovery activities. The Biostatistician will support the work of the CBA, ensuring that all experiments are designed optimally by systematically analyzing existing approaches and proposing practical and pragmatic enhancements or alternatives. Furthermore, they will develop, validate and implement quality control and analysis techniques for data generated by the CBA. They will be expected to proactively seek opportunities to contribute; influencing at all levels from operational managers to senior leaders.
The incumbent will report to the Director of the CBA and have a formal supervisory relationship with the Associate Director of Computational Sciences.
Success in this role will require:
Broad experience in statistics, and knowledge pertinent to the design, analysis and reporting of mouse phenotyping experiments including at least some of the following areas: experimental design, linear/nonlinear models, mixed effect models, Bayesian methods, and statistical/machine learning.
Programming proficiency and experience with relevant software tools such as R, Shiny, Stan, JMP and/or SAS.
Effective communication with key stakeholder groups including statisticians, software developers, informaticians, operational managers, animal care and use committee members, biological experts and Principal Investigators.
Key Responsibilities:
Provide Statistical Support to CBA Staff and Users (70%) - This should include, but not be limited to:
Development, optimization and validation of experimental design for individual biological assays and complex phenotyping pipelines.
Design and implementation of quality control and quality assurance procedures.
Design and implementation of analysis methodologies appropriate for the types of data generated but the CBA.
Synthesis of data into succinct, reproducible and understandable reports for distribution to users.
Proactive identification of opportunities to improve practices, streamline analysis, maximize data value and minimize animal usage.
Work with scientific and support staff to assist in grant preparation, with particular reference to experimental design, sample sizes, and statistical/analytical methodology.
Serve as primary support person to lead biostatistician on large, complex projects.
Maintenance and Communication of Good Statistical Practice (20%)
Initiate, maintain and develop relationships with key stakeholder groups within The Jackson Laboratory (JAX) including biostatisticians, software developers and informaticians within Computational Sciences and Faculty laboratories, as well as operational managers, animal care and use committee members, biological experts and Principal Investigators, to discuss, explain and develop new practices, and provide training in their implementation and interpretation.
Maintain and extend a professional network external to JAX to keep abreast of the scientific literature, and ensure awareness of key developments in phenotypic trait identification and optimal data presentation techniques.
Provide training on statistical methodologies encompassing experimental design and data analysis in order to enhance the quality of JAX research. In some instances, instruct others in how to perform basic statistical analyses which they could execute themselves.
Write and edit relevant statistical methodological details for manuscripts and grants. Extract, manipulate, prepare and analyze data for publication.
Present seminars both internally at JAX and externally at scientific conferences and meetings describing independent or collaborative work conducted through this role.
Contribute to the development of software solutions befitting CBA requirements (5%)
Provide specifications and liaise with software developers to produce proof-of-concept systems for improved phenotypic data presentation, data analysis tools, QC, and interfaces. Validate and test final analysis and presentation systems.
Requirements:
Essential skills and qualifications:
MS. in biostatistics, statistics, statistical genetics, bioinformatics, or science-related field (e.g., biology, zoology, genetics) and at least three years of appropriate experience relative to this position, or PhD. in biostatistics, statistics, statistical genetics, bioinformatics, or a related field
Broad experience in statistical data analysis of small to large dimensions, and knowledge of at least some of the following areas: experimental design, linear/nonlinear models, mixed effect models, multivariate statistical analyses, handling of missing data, Bayesian methods, and statistical/machine learning
Programming proficiency and experience with some of the relevant software tools such:
Data visualization and reporting tools that can be used for quality control and project monitoring activities (e.g. Tableau, Power BI, R/ggplot2)
Statistical analysis tools (e.g. R, Shiny, JMP, Stan, SAS).
Statistical analysis reporting tools that provide transparent and reproducible reporting of biological data (e.g. R Markdown)
Bioinformatics tools that allow data mining and interpretation (e.g. Ensembl, UCSC Genome Browser, PhenoDigm, Ingenuity Pathway Analysis)
Excellent initiative and organizational skills to prioritize complex tasks, projects, and workflow, and use independent judgment to make decisions regarding operations and deadlines
Proven ability to analyze and synthesize information, and demonstrated resourcefulness in finding appropriate solutions to problems and initiative in presenting alternatives and implementing solutions to ensure effective change and/or eliminate or mitigate potential negative effects
Excellent consulting, communication, training and presentation skills, in person and in writing, to clearly exchange information with people representing a wide diversity of disciplines and levels of sophistication, especially in communicating statistical concepts to non-statisticians
Exceptional organizational and project management skills, including the ability to plan, schedule, and successfully carry out multiple projects at the same time to successful conclusion with minimal supervision
Demonstrated positive attitude and professional manner in all interactions; demonstrated commitment to continuous learning and professional development
Quality orientated including delivering accuracy and attention to detail
Ability to work under pressure
Ability to work in a team and lead technical aspects of a team
Desired skills and qualifications:
Knowledge and ability to program in conventional languages (e.g. Perl) and formulate data queried in SQL
Familiarity with wet lab operation and techniques by which data are generated or could be generated
Familiarity with the ARRIVE guidelines (Kilkenny et al.) and the 3Rs philosophy governing the use of animals in biological experimentation
About us:
The Jackson Laboratory (JAX, www.jax.org) is a nonprofit biomedical research institute with over 2,000 employees whose mission is to discover precise genomic solutions for human disease and empower the global biomedical community in the shared quest to improve human health. A National Cancer Institute-designated Cancer Center, JAX has a mammalian genetics headquarters in Bar Harbor, Maine, a facility in Sacramento, California, and a genomic medicine facility, The Jackson Laboratory for Genomic Medicine (JAX-GM), in Farmington, Connecticut.
The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries.
JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients' lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 "Best Places to Work in Academia" in the United States in a poll conducted by The Scientist magazine!
Our Values:
INTEGRITY - Courage and commitment to do what is right
PEOPLE - Inspiring our people to enhance the health of all
ONE TEAM - Unified by our promise to transform medicine and science
EXCELLENCE - Achieving world-class results
INNOVATION - Leading with discovery and creative solutions
STEWARDSHIP - Caring for and enhancing the resources entrusted to us
What do we have to offer?
JAX offers a dynamic and supportive work environment, competitive salaries, and a comprehensive benefits package, including a medical plan, outstanding retirement plan, generous paid time off, and tuition reimbursement including an MBA program. Our campus offers a fitness center with an award-winning wellness program, an onsite full service cafeteria, and a fully operational primary care facility available to employees and their families.
Most importantly, every position contributes to JAX's mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.
Learn more about career opportunities at JAX: http://www.jax.org/careers.

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